SVA_E
Basic information Differential Expression Stage analysis Survival analysis Correlation analysis| DF ID | DF0001071 |
|---|---|
| TE superfamily | SVA |
| TE class | Retroposon |
| Species | Homo_sapiens |
| Length | 1382 |
| Kimura value | 7.57 |
| Tau index | 0.9342 |
| Description | Composite retroelement: (SINE-R + VNTR + Alu), SVA_E subfamily |
| Comment | SVA retroelements are hominid-specific chimeras, some of which are still active in the human population. These SINEs are a unique combination of features. The 5' end begins with hexamer repeats, followed by two Alus in reverse orientation. The center is comprised of a number of VNTR regions (Variable Number of Tandem Repeats) that may span a few hundred basepairs, up to 2Kbp. The 3' end is formed by a portion of a HERVK LTR (the SINE-R feature). SVA_E is still highly polymorphic in the human population. |
| Sequence |
CTCTCCCTCTCCCTCTCCCTCTCCCTCTCCCTCTCCCTCTCCCTCTCCCCTCCCTCCACGGTCTCCCTCTGATGCCGAGCCAAAGCTGGACGGTACTGCTGCCATCTCGGCTCACTGCAACCTCCCTGCCTGATTCTCCTGCCTCAGCCTGCCGAGTGCCTGCGATTGCAGGCGCGCGCCGCCACGCCTGACTGGTTTTCGTTTTTTTTTGGTGGAGACGGGGTCTCGCTGTGTTGNCCGGGCTGGTCTCCAGCTCCTGGCCGCGAGTGATCCGCCNGCCTCGGCCTCCCGAGGTGCCGGGATTGCAGACGGAGTCTCGTTCACTCAGTGCTCAATGGTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCGCTACAACCACCTCCCAGCCGCCTGCCTTGGCCTCCCAAAGAGCCGGATTGCAGCCTCTGCCCGGCCGCCGCCCCGTCCGGGAGGTGAGGAGCGCCTCTGCCCGGCCGCCCATCGTCCGGGANGTGAGGAGCCCCTCTGCCCGGCCGCCCCGTCCGGGAGGTGAGGAGCGCCTCTGCCCGGCCGCCGCCCCGTCTGGGAAGTGAGGAGCGCCTCTGCCCGGCCGCCCNNCGTCCGGGANGTGGGGAGCGCCTCCGCCCNGCCGCCCCGTCCGGGAGGTGAGGAGCGCCTCCGCCCGGCCAGCCGCCCCGTCCGGGAGGTGGGGGGGTCAGCCCCCCGCCCGGCCAGCCGCCCCGTCCGGGAGGAGGTGGGGGGGTCAGCCCCCCGCCCGGCCAGCCGCCCCGTCCGGGAGGTGAGGGGCGCCTCTGCCCGGCCGCCCCTACTGGGAAGTGAGGAGCCCCTCTGCCCGGCCACCGCCCCGTCCGGGAGGTGTGCCCAGCGGCTCATTGGGGATGGGCCATGATGACAATGGCGGTTTTGTGGAATAGAAAGGCGGGAAGGGTGGGGAAAAAATTGAGAAATCGGATGGTTGCCGGGTCTGTGTGGATAGAAGTAGACATGGGAGACTTTTCATTTTGTTCTGTACTAAGAAAAATTCTTCTGCCTTGGGATCCTGTTGATCTGTGACCTTATCCCCAACCCTGTGCTCTCTGAAACATGTGCTGTGTCCACTCAGGGTTAAATGGATTAAGGGCGGTGCAAGATGTGCTTTGTTAAACAGATGCTTGAAGGCAGCATGCTCGTTAAGAGTCATCACCACTCCCTAATCTTAAGTACCCAGGGACACAAACACTGCGGAAGGCCGCAGGGTCCTCTGCCTAGGAAAACCAGAGACCTTTGTTCACTTGTTTATCTGCTGACCTTCCCTCCACTATTGTCCTATGACCCTGCCAAATCCCCCTCTGCGAGAAACACCCAAGAATGATCAATAAAAAAAAAAAAAAAAAAAA
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TF motifs of the concenus sequence
Use FIMO to detect transcription factor motifs in the concenus sequence of the TE family.
| TE_family | TFBS | Start | End | Strand | Score | Matched sequence |
|---|---|---|---|---|---|---|
| SVA_E | EREB29 | 555 | 564 | + | 19.06 | GCCGCCGCCC |
| SVA_E | DOF3.6 | 1360 | 1380 | - | 19.03 | TTTTTTTTTTTTTTTTTTATT |
| SVA_E | BPC1 | 28 | 51 | - | 18.74 | AGGGGAGAGGGAGAGGGAGAGGGA |
| SVA_E | PAX8 | 180 | 195 | + | 18.29 | CGCCACGCCTGACTGG |
| SVA_E | SREBP | 357 | 366 | - | 18.13 | ATCACGCCAC |
| SVA_E | ZNF213 | 340 | 351 | + | 18.09 | GCCCAGGCTGGA |
| SVA_E | Zm00001d020267 | 438 | 447 | + | 17.95 | GGCCGCCGCC |
| SVA_E | Zm00001d020267 | 554 | 563 | + | 17.95 | GGCCGCCGCC |
| SVA_E | BPC6 | 11 | 31 | + | 17.91 | CCCTCTCCCTCTCCCTCTCCC |
| SVA_E | BPC6 | 17 | 37 | + | 17.91 | CCCTCTCCCTCTCCCTCTCCC |
TFBS enrichment in GRCh38
Use Fisher's exact test to perform enrichment analysis of transcription factor binding sites in the TE family of GRCh38.
