LTR12F

Basic information Differential Expression Stage analysis Survival analysis Correlation analysis

DF ID DF0000405
TE superfamily ERV1
TE class LTR
Species Catarrhini
Length 519
Kimura value 6.71
Tau index 0.9044
Description Long terminal repeat of class I endogenous retrovirus HERV9
Comment Positions 73-207 of the consensus contains 5 copies of a 23-bp-period tandem repeat interrupted by a 15 bp sequence. The number of units at any locus is variable. Matches limited to pos. ~334 to 411 represent retroposed copies of the region of the LTR between the transcription initiation and termination signals (named R as it Repeats at the ends of the transcript). They are followed by a poly A tail and were likely introduced by the LINE1 machinery. They could be the result of R-R recombination of a LINE1-retroposed full transcripts, though no full processed psuedogenes of HERV9 with LTR12F LTRs survived. Slight target site duplication preference for MTAK.
Sequence
TGAGAGGTGAAGCCAGCTGGACTTCCTGGGTCGAGTGGGGACTTGGAGAACTTTTCTGTCTTACAAGAGGATTGTAAAATGCACCAATCAGCGCTCTGTAAAAACGCACCAATCAGCGCTCTGTAGCTAGCAAGAGGATTGTAAAATGCACCAATCAGCGCTCTGTAAAACGCACCAATCAGCGCTCTGTAAAACGCACCAATCAGCAGGATTCTAAAAGTAGCCAATCGCGGGGAGGATTGAAAAAAGGGCACTCTGATAGGACAGAAACGGAACATGGGAGGGGACAAATAAGGGAATAAAAGCTGGCCACCCCAGCCAGCAGCGGCAACCCGCTCGGGTCCCCTTCCACGCTGTGGAAGCTTTGTTCTTTCGCTCTTCACAATAAACCTTGCTGCCGCTCACTCTTTGGGTCCGTGCCATCTTTAAGAGCTGTAACACTCACCGCGAAGGTCCGCGGCTTCATTCTTGAAGTCAGCGAGACCACGAACCCACCGGNAGGAACCAACTCCGGACACA



TF motifs of the concenus sequence

Use FIMO to detect transcription factor motifs in the concenus sequence of the TE family.

TE_family TFBS Start End Strand Score Matched sequence
LTR12F ZNF454 476 492 - 13.63 GGTTCGTGGTCTCGCTG
LTR12F ELF1 20 28 - 13.54 CAGGAAGTC
LTR12F KLF5 278 287 - 13.47 TCCCCTCCCA
LTR12F AP1 287 299 + 13.46 ACAAATAAGGGAA
LTR12F BZIP18 11 20 + 13.44 AGCCAGCTGG
LTR12F EHF 20 28 + 13.23 GACTTCCTG
LTR12F KLF1 279 286 + 13.17 GGGAGGGG
LTR12F PK27109.1 12 19 + 13.03 GCCAGCTG
LTR12F ELF3 20 28 + 13.00 GACTTCCTG
LTR12F HAP3 222 230 - 12.92 CGATTGGCT


TFBS enrichment in GRCh38

Use Fisher's exact test to perform enrichment analysis of transcription factor binding sites in the TE family of GRCh38.




GTEx

The promoter activity across 46 body sites from The Genotype-Tissue Expression (GTEx) project.




TCGA

The promoter activity across 33 cancer types from The Cancer Genome Atlas (TCGA).