LTR12F

Basic information Differential Expression Stage analysis Survival analysis Correlation analysis

DF ID DF0000405
TE superfamily ERV1
TE class LTR
Species Catarrhini
Length 519
Kimura value 6.71
Tau index 0.9044
Description Long terminal repeat of class I endogenous retrovirus HERV9
Comment Positions 73-207 of the consensus contains 5 copies of a 23-bp-period tandem repeat interrupted by a 15 bp sequence. The number of units at any locus is variable. Matches limited to pos. ~334 to 411 represent retroposed copies of the region of the LTR between the transcription initiation and termination signals (named R as it Repeats at the ends of the transcript). They are followed by a poly A tail and were likely introduced by the LINE1 machinery. They could be the result of R-R recombination of a LINE1-retroposed full transcripts, though no full processed psuedogenes of HERV9 with LTR12F LTRs survived. Slight target site duplication preference for MTAK.
Sequence
TGAGAGGTGAAGCCAGCTGGACTTCCTGGGTCGAGTGGGGACTTGGAGAACTTTTCTGTCTTACAAGAGGATTGTAAAATGCACCAATCAGCGCTCTGTAAAAACGCACCAATCAGCGCTCTGTAGCTAGCAAGAGGATTGTAAAATGCACCAATCAGCGCTCTGTAAAACGCACCAATCAGCGCTCTGTAAAACGCACCAATCAGCAGGATTCTAAAAGTAGCCAATCGCGGGGAGGATTGAAAAAAGGGCACTCTGATAGGACAGAAACGGAACATGGGAGGGGACAAATAAGGGAATAAAAGCTGGCCACCCCAGCCAGCAGCGGCAACCCGCTCGGGTCCCCTTCCACGCTGTGGAAGCTTTGTTCTTTCGCTCTTCACAATAAACCTTGCTGCCGCTCACTCTTTGGGTCCGTGCCATCTTTAAGAGCTGTAACACTCACCGCGAAGGTCCGCGGCTTCATTCTTGAAGTCAGCGAGACCACGAACCCACCGGNAGGAACCAACTCCGGACACA



TF motifs of the concenus sequence

Use FIMO to detect transcription factor motifs in the concenus sequence of the TE family.

TE_family TFBS Start End Strand Score Matched sequence
LTR12F NFYA 175 182 + 14.54 CCAATCAG
LTR12F NFYA 199 206 + 14.54 CCAATCAG
LTR12F NFYA 84 91 + 14.54 CCAATCAG
LTR12F Sox11 363 370 - 14.51 GAACAAAG
LTR12F ZNF766 384 392 + 14.38 AATAAACCT
LTR12F nit-4 454 460 + 14.25 TCCGCGG
LTR12F HAP5 108 121 - 14.04 GAGCGCTGATTGGT
LTR12F HAP5 150 163 - 14.04 GAGCGCTGATTGGT
LTR12F HAP5 174 187 - 14.04 GAGCGCTGATTGGT
LTR12F HAP5 83 96 - 14.04 GAGCGCTGATTGGT


TFBS enrichment in GRCh38

Use Fisher's exact test to perform enrichment analysis of transcription factor binding sites in the TE family of GRCh38.




GTEx

The promoter activity across 46 body sites from The Genotype-Tissue Expression (GTEx) project.




TCGA

The promoter activity across 33 cancer types from The Cancer Genome Atlas (TCGA).